Substitution Reaction Definition

Substitution Reaction Definition

A substitution reaction is a type of chemical reaction where an atom or functional group of a molecule is replaced by another atom or functional group.

A substitution reaction is also called a single displacement reaction, single replacement reaction, or single substitution reaction.

Examples: CH3Cl reacted with a hydroxy ion (OH-) will produce CH3OH and chlorine. This substitution reaction replaces the chlorine atom on the original molecule with the hydroxy ion.


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  • March, Jerry (1985). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (3rd ed.). New York: Wiley. ISBN 0-471-85472-7.